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Apexbio Technology LLC Ursodiol 128-13-2 1g
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Supplier:  Apexbio Technology LLC B21351000

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Ursodiol (CAS 128-13-2) also known as ursodeoxycholic acid is a bile acid commonly utilized in the treatment of primary biliary cholangitis (PBC) Mechanistically ursodiol interferes with the progression of PBC and enhances patient survival In cellular models ursodiol has been shown to dose-dependently inhibit the viability of HepG2 and BEL7402 hepatoma cells with IC50 values of 0 92 mmol/L and 0 86 mmol/L respectively while significantly promoting apoptosis in these lines Western blot analyses reveal that ursodiol downregulates the expression of cell cycle regulators including cyclin D1 cyclin D3 Cdk2 and Cdk4 Its antiproliferative and pro-apoptotic properties underscore its value in studies of liver disease and oncogenesis

Catalog No. 50-224-0829


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