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Medchemexpress LLC USP5-IN-1 | 2851040-81-6 | 99.7% | 437.90 | 1 MG
SDP

Catalog No. 5000351073
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USP5-IN-1 is a selective competitive inhibitor of the USP5 zinc finger ubiquitin binding domain (ZnF-UBD) with a KD of 2.8 μM. It functions by blocking the binding of ubiquitin to ZnF-UBD, which inhibits the catalytic activity of USP5 and hinders the hydrolysis of ubiquitin chains. This compound can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is considered a potential USP5 chemical probe and inhibitor for USP5-related cancers.

  • Selectively inhibits USP5 zinc finger ubiquitin binding domain (ZnF-UBD)
  • Shows ≥30-fold selectivity over 9 homologous ZnF-UBD proteins
  • Inhibits USP5 cleavage of Lys48-linked diubiquitin substrates in vitro
  • Potential chemical probe for USP5 research
  • Potential inhibitor for cancers related to USP5 activity

Catalog No. 50-003-51073 Supplier Medchemexpress LLC Supplier No. HY1399791MG
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USP5-IN-1 is a selective competitive inhibitor of the USP5 zinc finger ubiquitin binding domain (ZnF-UBD) with a KD of 2.8 μM. It functions by blocking the binding of ubiquitin to ZnF-UBD, which inhibits the catalytic activity of USP5 and hinders the hydrolysis of ubiquitin chains. This compound can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is considered a potential USP5 chemical probe and inhibitor for USP5-related cancers.

  • Selectively inhibits USP5 zinc finger ubiquitin binding domain (ZnF-UBD)
  • Shows ≥30-fold selectivity over 9 homologous ZnF-UBD proteins
  • Inhibits USP5 cleavage of Lys48-linked diubiquitin substrates in vitro
  • Potential chemical probe for USP5 research
  • Potential inhibitor for cancers related to USP5 activity

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