Medchemexpress LLC V-9302 | 1855871-76-9 | 99.5% | 538.68 | 100 MG

Supplier:  Medchemexpress LLC HY112683100MG

V-9302 is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) but not ASCT1, inhibiting ASCT2-mediated glutamine uptake in HEK-293 cells.

• Selectively targets the amino acid transporter ASCT2 (SLC1A5) over ASCT1.
• Inhibits glutamine uptake (IC50=9.6 μM) in HEK-293 cells.
• Pharmacological blockade of ASCT2 leads to attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress.
• Prevents tumor growth in HCT-116 and HT29 xenograft models (75 mg/kg; i.p.; daily for 21 days).
• When combined with CB-839, it elicits strong growth inhibition in SNU398 and MHCC97H xenograft models.
• High purity: 99.46%.
• Intended for research use only, not for sale to patients.

Catalog No. 50-004-35610