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Medchemexpress LLC V-9302 hydrochloride | 2416138-42-4 | 99.1% | 575.14 | 10 MG
Supplier: Medchemexpress LLC HY112683A10MG
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) over ASCT1, inhibiting ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells. Pharmacological blockade of ASCT2 with V-9302 hydrochloride leads to attenuated cancer cell growth and proliferation, increased cell death, and increased oxidative stress.
- Selectively and potently targets the amino acid transporter ASCT2 (SLC1A5).
- Inhibits ASCT2-mediated glutamine uptake in HEK-293 cells.
- Attenuates cancer cell growth and proliferation.
- Increases cell death and oxidative stress.
- Prevents tumor growth in xenograft models.
- Elicits strong growth inhibition in combination therapies.
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