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Medchemexpress LLC V-9302 hydrochloride | 2416138-42-4 | 99.1% | 575.14 | 25 MG
Supplier: Medchemexpress LLC 25MGHY112683A
V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. It selectively and potently targets the amino acid transporter ASCT2 (SLC1A5), but not ASCT1. It inhibits ASCT2-mediated glutamine uptake with an IC50 of 9.6 μM in HEK-293 cells.
- Inhibits ASCT2-mediated glutamine uptake in human cells.
- Shows improved potency over gamma-L-glutamyl-p-nitroanilide.
- Attenuates cancer cell growth and proliferation.
- Increases cell death and oxidative stress.
- Prevents tumor growth in xenograft models.
- Elicits strong growth inhibition in xenograft models when combined with CB-839.
- Reduces tumor growth.
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