Meso Scale Discovery V-PLEX HUMAN IL-10 KIT

Supplier:  Meso Scale Discovery K151QUD1

Human interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor (CSIF), is a 20.5 kDa, glycosylated homodimeric cytokine with two disulfide bonds. The homodimer binds to two IL-10 R subunits resulting in recruitment of two IL-10 R chains to initiate the IL-10 mediated signal cascades. IL-10 R is also associated with receptors of IL-22, IL-26, IL-28, and IL-29. IL-10 inhibits the synthesis of numerous cytokines (including IFN-, IL-2, IL-3, TNF-, TNF-, and GM-CSF) that suppress Th1 proinflammatory responses and promote phagocytic uptake. IL-10 has been shown to prevent liver necrosis during parasitic infection in mice.The Human IL-10 Kit provides the assay-specific components for the quantitative determination of endogenous IL-10 in human urine, serum, plasma, and cell culture supernatants.

Catalog No. NC1958812