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Medchemexpress LLC Val-083 (dianhydrodulcitol) | 23261-20-3 | 98.0% | 146.14 | 10 MG
SDP

Catalog No. 5000365081
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VAL-083 is an alkylating agent that creates N7 methylation on DNA, exhibiting antitumor activity. It is intended for research use only and is not sold to patients.

  • Suppresses U251 and SF188 cell growth; induces apoptosis.
  • Inhibits T98G cell growth dose-dependently (IC50 <5 μM).
  • Reduces HUVEC and U251 cell proliferation, migration, and invasion.
  • Decreases MMP2, VEGF, VEGFR2, and FGF2 expression.
  • Induces G2/M phase cell cycle arrest in glioma cell lines.
  • Activates p53-p21 and CDC25C-CDK1 signaling cascades, enhancing radiosensitivity.
  • Inhibits angiogenesis in zebrafish models.
  • Blocks LN229 cell growth in mice.
  • Activates CDC25C-CDK1 cascade in xenografted tumors.

Catalog No. 50-003-65081 Supplier Medchemexpress LLC Supplier No. 10MGHY16513
May include imposed supplier surcharges.
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VAL-083 is an alkylating agent that creates N7 methylation on DNA, exhibiting antitumor activity. It is intended for research use only and is not sold to patients.

  • Suppresses U251 and SF188 cell growth; induces apoptosis.
  • Inhibits T98G cell growth dose-dependently (IC50 <5 μM).
  • Reduces HUVEC and U251 cell proliferation, migration, and invasion.
  • Decreases MMP2, VEGF, VEGFR2, and FGF2 expression.
  • Induces G2/M phase cell cycle arrest in glioma cell lines.
  • Activates p53-p21 and CDC25C-CDK1 signaling cascades, enhancing radiosensitivity.
  • Inhibits angiogenesis in zebrafish models.
  • Blocks LN229 cell growth in mice.
  • Activates CDC25C-CDK1 cascade in xenografted tumors.

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