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Medchemexpress LLC Val-cit-PAB-OH | 159857-79-1 | 379.45 | C18H29N5O4 | 25 G
Supplier: Medchemexpress LLC HY1236225G
Val-cit-PAB-OH is a cleavable, protease-sensitive antibody-drug conjugate (ADC) linker that couples cytotoxic payloads to antibodies through a valine-citrulline dipeptide and a para-aminobenzyl (PAB) self-immolative spacer. It is designed to remain stable in circulation and release payloads upon intracellular protease cleavage, supporting targeted delivery in ADC synthesis.
- Cleavable by intracellular proteases via valine-citrulline mechanism.
- Stable in systemic circulation, reducing premature payload release.
- Enables self-immolative payload release through a PAB spacer.
- Compatible with common conjugation chemistries for ADC construction.
- Available in gram-scale quantities for research and scale-up synthesis.
- Supplied with manufacturer storage guidance for long-term stability.
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