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Apexbio Technology LLC Valproic acid(Synonyms: 2-Propylpentanoic acid, VPA, Depakene, Valproate, Dipropylacetic acid), 5g, CAS: 99-66-1.
Supplier: Apexbio Technology LLC B12515000
Valproic acid (CAS 99-66-1) is a branched short-chain fatty acid originally developed as an inert organic solvent later identified for anticonvulsant properties in animal models Mechanistically valproic acid enhances levels of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) by increasing synthesis inhibiting degradation and blocking GABA transaminase activity It also modulates neuronal excitability via inhibition of voltage-gated sodium calcium and potassium channels Furthermore valproic acid acts as a histone deacetylase (HDAC) inhibitor targeting HDAC1 with an IC50 of approximately 0 4 mM Due to HDAC inhibitory activity it holds potential research interest for oncology applications
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