Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Apexbio Technology LLC Vanoxerine dihydrochloride 67469-78-7 50mg
Supplier: Apexbio Technology LLC B324850
Vanoxerine dihydrochloride is a small-molecule inhibitor targeting the dopamine transporter (DAT1) human ether- -go-go-related gene (hERG Kv11 1) potassium channel cardiac sodium channel (hNaV1 5) and L-type calcium channels (ICa L) It modulates neurotransmitter uptake and cardiac ion channel conductance thereby regulating synaptic dopamine levels and cardiac electrophysiology Vanoxerine dihydrochloride exerts its biological activity primarily through inhibition of dopamine reuptake and blockade of multiple cardiac ion channels It demonstrates antagonist activity at DAT1 (Ki 16 9 nM) potent inhibition of hERG channels (IC50 0 84 nM) and inhibitory effects on hNaV1 5 (IC50 830 nM) and ICa L (IC50 320 nM) Based on these pharmacological properties vanoxerine dihydrochloride holds research potential in cardiac arrhythmia studies
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?