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Medchemexpress LLC Vapreotide acetate | 849479-74-9 | >98.16% | 1191.42 | 25 MG
SDP

Catalog No. 5000426871
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Vapreotide acetate is a neurokinin-1 (NK1) receptor antagonist, characterized by an IC50 of 330 nM. It attenuates Substance P (SP)-triggered intracellular calcium increases and NF-κB activation, while inhibiting SP-induced IL-8 and MCP-1 production. It also inhibits HIV-1 infection and significantly reduces GH-, PRL, and/or alpha-subunit release from pituitary adenoma cells. The compound exhibits moderate-to-high affinities for SSTR2, -3, and -5.

  • Neurokinin-1 (NK1) receptor antagonist.
  • Attenuates SP-triggered calcium increases, NF-κB activation.
  • Inhibits SP-induced IL-8 and MCP-1 production.
  • Inhibits HIV-1 infection; reduces GH, PRL, and alpha-subunit release.
  • Moderate-to-high affinities for SSTR2, -3, and -5.
  • Can inhibit androgen-independent prostate cancer growth and decrease collateral circulation in cirrhotic rats.

Catalog No. 50-004-26871 Supplier Medchemexpress LLC Supplier No. 25MGHYP0061A
May include imposed supplier surcharges.
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Vapreotide acetate is a neurokinin-1 (NK1) receptor antagonist, characterized by an IC50 of 330 nM. It attenuates Substance P (SP)-triggered intracellular calcium increases and NF-κB activation, while inhibiting SP-induced IL-8 and MCP-1 production. It also inhibits HIV-1 infection and significantly reduces GH-, PRL, and/or alpha-subunit release from pituitary adenoma cells. The compound exhibits moderate-to-high affinities for SSTR2, -3, and -5.

  • Neurokinin-1 (NK1) receptor antagonist.
  • Attenuates SP-triggered calcium increases, NF-κB activation.
  • Inhibits SP-induced IL-8 and MCP-1 production.
  • Inhibits HIV-1 infection; reduces GH, PRL, and alpha-subunit release.
  • Moderate-to-high affinities for SSTR2, -3, and -5.
  • Can inhibit androgen-independent prostate cancer growth and decrease collateral circulation in cirrhotic rats.

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