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Medchemexpress LLC Vardenafil hydrochloride trihydrate | 330808-88-3 | 100 MG
Supplier: Medchemexpress LLC HYB0442B100MG
Vardenafil hydrochloride trihydrate is a selective and orally active inhibitor of phosphodiesterase-5 (PDE5), with an IC50 of 0.7 nM. It exhibits inhibitory activity against PDE1 (IC50 of 180 nM) and PDE6 (IC50 of 11 nM), while its IC50s are greater than 1000 nM for PDE3 and PDE4. This compound functions by competitively inhibiting cyclic guanosine monophosphate (cGMP) hydrolysis, thereby increasing cGMP levels. It is utilized in research for applications related to erectile dysfunction, hepatitis, and diabetes.
- Selective and orally active PDE5 inhibitor
- Competitively inhibits cGMP hydrolysis
- Increases cGMP levels
- Useful for research on erectile dysfunction, hepatitis, and diabetes
- IC50 for PDE5: 0.7 nM
- IC50 for PDE6: 11 nM
- IC50 for PDE1: 180 nM
- IC50 for PDE3: >1000 nM
- IC50 for PDE4: >1000 nM
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