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Medchemexpress LLC VAS 3947 | 869853-70-3 | 99.59% | 310.33 | 50 MG
Supplier: Medchemexpress LLC HY11144750MG
VAS 3947 is a specific NADPH oxidase (NOX) inhibitor that exerts a potent antiplatelet effect. It induces apoptosis independently of anti-NOX activity, primarily through UPR activation, due to protein aggregation and misfolding.
- Consistently inhibits NADPH oxidase activity in low micromolar concentrations.
- Does not interfere with ROS detection, XOD, or eNOS activities.
- Triggers cell proliferation arrest and death.
- Decreases ROS levels and triggers endoplasmic reticulum (ER) stress and consequent unfolding protein response (UPR).
- Attenuates platelet activation and thrombus formation via a NOX-independent pathway downstream of PKC.
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