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Abcam Vatalanib dihydrochloride, VEGFR tyrosine kinase inhibitor, 50MG

Catalog No. 502706285
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MW 419.7 Da, Purity >98%. Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1) and VEGFR-2 (FLK-1/KDR) (IC₅₀ values are 77 nM and 37 nM respectively). Weaker inhibitor of other tyrosine kinases including PDGFR-β, c-KIT, VEGFR-3 (FLT-4) and c-FMS (IC₅₀ values are 580 nM, 730 nM, 660 nM and 1.4 μM respectively). Inactive against EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 μM). Induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model.

The product is subject to the following: Abcam Restricted Use Statement

Catalog No. 50-270-6285 Supplier Abcam Supplier No. AB14219950MG
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MW 419.7 Da, Purity >98%. Cell-permeable, potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1) and VEGFR-2 (FLK-1/KDR) (IC₅₀ values are 77 nM and 37 nM respectively). Weaker inhibitor of other tyrosine kinases including PDGFR-β, c-KIT, VEGFR-3 (FLT-4) and c-FMS (IC₅₀ values are 580 nM, 730 nM, 660 nM and 1.4 μM respectively). Inactive against EGFR, c-SRC, v-ABL, and protein kinase Cα (IC₅₀ > 10 μM). Induces dose-dependent inhibition of VEGF and PDGF-induced angiogenesis in a growth factor implant model.

The product is subject to the following: Abcam Restricted Use Statement

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