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Medchemexpress LLC VE-821 | 1232410-49-9 | 99.7% | 368.41 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY14731100MG

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VE-821 is a potent ATP-competitive inhibitor of ATR with Ki/IC50 values of 13 nM/26 nM. It exhibits excellent selectivity for ATR, demonstrating minimal cross-reactivity with related PIKKs like ATM, DNA-PK, mTOR, and PI3Kγ. This compound enhances the sensitivity of pancreatic cancer cells (PSN-1, MiaPaCa-2, and primary PancM) to radiation and Gemcitabine under both normoxic and hypoxic conditions. ATR inhibition by VE-821 also leads to the inhibition of radiation-induced G2/M arrest in cancer cells.

  • Potent ATP-competitive inhibitor of ATR (Ki/IC50 of 13 nM/26 nM)
  • Exhibits excellent selectivity for ATR with minimal cross-reactivity against related PIKKs
  • Enhances sensitivity of pancreatic cancer cells to radiation and Gemcitabine
  • Inhibits radiation-induced G2/M arrest in cancer cells
  • Inhibits phosphorylation of Chk1 (Ser 345) after specific treatments

Catalog No. 50-003-60683


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