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Medchemexpress LLC VE-821 | 1232410-49-9 | 99.7% | 368.41 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1473150MG

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VE-821 is a potent ATP-competitive inhibitor of ATR, with Ki/IC50 values of 13 nM/26 nM. It demonstrates excellent selectivity for ATR, showing minimal cross-reactivity against related PIKKs such as ATM, DNA-PK, mTOR, and PI3Kγ.

  • Shows minimal cross-reactivity against related PIKKs ATM, DNA-PK, mTOR, and PI3Kγ
  • Significantly enhances the sensitivity of PSN-1, MiaPaCa-2, and primary PancM pancreatic cancer cells to radiation and Gemcitabine
  • ATR inhibition by VE-821 leads to inhibition of radiation-induced G2/M arrest in cancer cells
  • Inhibits phosphorylation of Chk1 (Ser 345) in PSN-1 and MiaPaCa-2 cells after treatment with Gemcitabine, radiation, or both

Catalog No. 50-003-62107


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