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Genscript Corporation Antibody Protein Proteins Proteins 10 UG 1/EA
Supplier: Genscript Corporation Z0314010
VEGF-A121 is one of five isoforms (121 145 165 189 and 206) of VEGF protein a cytokine belonging to the Platelet Differentiation Growth Factor (PDGF) family and existing as a disulfide-linked homodimeric glycoprotein. In contrast to the longer isoforms VEGF-A121 is more freely diffusible and cannot bind to heparin. In vivo VEGF is expressed predominantly in lung heart kidney and adrenal glands and the expression of VEGF is up-regulated by a number of growth factors including PDGF Fibroblast Growth Factor (FGF) Epidermal Growth Factor (EGF) and Tumor Necrosis Factor (TNF). VEGF signals via binding to two tyrosine kinase receptors: the Fms-like tyrosine kinase 1 (Flt-1) and the kinase domain receptor (KDR). VEGF is a specific mitogen and survival factor contributing to abnormal angiogenesis and cancer development.
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