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AdipoGen VEGFR-1 h mAb EWC
Supplier: AdipoGen AG20T0106C100
Monoclonal Antibody. The antibody will detect native human VEGFR-1/Flt-1 in ELISA experiments and on the surface of different human cell types. Isotype Mouse IgG1. Clone EWC. Applications ELISA, WB. Lyophilized. Recombinant human soluble vascular endothelial growth factor receptor-1 sVEGFR-1 is the naturally occurring form and is a glycosylated monomeric protein. The biological function of sVEGFR-1 seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. VEGFR-1 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells.
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