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AdipoGen VEGFR-1 Soluble h rec
Supplier: AdipoGen AG40T0049C020
Protein. Human sVEGFR-1 663aa. Source Sf9 cells. Lyophilized. Purity >95% SDS-PAGE. Recombinant human soluble vascular endothelial growth factor receptor-1 sVEGFR-1 is the naturally occurring form and is a glycosylated monomeric protein. The biological function of sVEGFR-1 seems to be an endogenous regulator of angiogenesis, binding VEGF with the same affinity as the full-length receptor. VEGFR-1 is a tyrosine-protein kinase that acts as a cell-surface receptor for VEGFA, VEGFB and PGF, and plays an essential role in the development of embryonic vasculature, the regulation of angiogenesis, cell survival, cell migration, macrophage function, chemotaxis and cancer cell invasion. It may play an essential role as a negative regulator of embryonic angiogenesis by inhibiting excessive proliferation of endothelial cells. It can promote endothelial cell proliferation, survival and angiogenesis in adulthood. Its function in promoting cell proliferation seems to be cell-type specific.
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