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Apexbio Technology LLC Vemurafenib (PLX4032, RG7204) 918504-65-1 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A30045.1
Vemurafenib (PLX4032 RG7204 CAS 918504-65-1) is a small-molecule inhibitor targeting BRAF kinase primarily inhibiting the activity of the oncogenic BRAF V600E mutant by competitively binding its ATP-binding site It also inhibits related kinases such as CRAF ARAF and wild-type BRAF In cells lacking BRAF mutations vemurafenib may paradoxically stimulate downstream MEK signalling due to transactivation mechanisms within RAF dimers Vemurafenib serves as an important research tool for investigating RAF-mediated signaling pathways in oncology particularly in melanoma studies
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