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Apexbio Technology LLC Verdinexor (KPT-335) 1392136-43-4 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC B48895.1
Verdinexor (KPT-335 CAS 1392136-43-4) is a selective inhibitor of nuclear export (SINE) targeting exportin-1 (XPO1) a protein that mediates nuclear export of various cargos critical in cell proliferation and cycle regulation Verdinexor treatment in influenza A- or B-infected A549 cells leads to nuclear accumulation of viral ribonucleoproteins (vRNP) and altered localization of viral NS1 protein effectively blocking nuclear export and viral replication In mouse models infected with influenza A virus verdinexor significantly reduces pulmonary viral titers and inflammatory cytokine expression Additionally verdinexor exhibits cytotoxic activity against canine lymphoma cells Therefore verdinexor serves as a valuable tool compound in antiviral and oncology research
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