Apexbio Technology LLC Verteporfin 129497-78-5 10mM (in 1mL DMSO)

Supplier:  Apexbio Technology LLC A83275.1

Verteporfin (CAS 129497-78-5) is a porphyrin-derived small molecule used as a photosensitizer in photodynamic therapy (PDT) Upon photoactivation verteporfin induces targeted vascular endothelial cytotoxicity through intravascular damage and thrombosis formation leading to selective vessel closure Experimental studies indicate verteporfin treatment triggers DNA fragmentation and enhances apoptotic events in vitro displaying potent cytotoxicity against HL-60 cells at concentrations around 100 ng/mL Independently of photoactivation verteporfin also directly modifies and inhibits the autophagy adaptor protein p62 impacting its binding to polyubiquitinated substrates Verteporfin is relevant to biomedical research involving PDT mechanisms autophagy pathways and angiogenesis

Catalog No. 50-000-61709