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Medchemexpress LLC (±)-Vesamicol hydrochloride | 120447-62-3 | 99.8% | 25 MG
Supplier: Medchemexpress LLC 25MGHYB1813A
(±)-Vesamicol hydrochloride ((±)-AH5183 hydrochloride) is a potent vesicular acetylcholine transport inhibitor with a Ki of 2 nM. It also displays high affinity for σ1 and σ2 receptors with Kis of 26 nM and 34 nM, respectively. The pharmacological actions of (±)-Vesamicol are attributed to the inhibition of acetylcholine transport into synaptic vesicles and subsequent quantal release of acetylcholine.
- Potent vesicular acetylcholine transport inhibitor
- Displays high affinity for σ1 and σ2 receptors
- Inhibits acetylcholine transport into synaptic vesicles
- Reduces subsequent quantal release of acetylcholine
- Increases cytosolic acetylcholine levels in rat brain
- Decreases vesicular acetylcholine levels in rat brain (except striatum)
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