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Medchemexpress LLC VH032 thiol | 2098836-54-3 | 490.64 | 1 MG
SDP

Catalog No. 5000440002
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VH032 thiol (VHL ligand 6) is a VHL ligand that binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

  • Binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.
  • Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes.
  • Induces ubiquitination and subsequent proteasomal degradation of target proteins.

Catalog No. 50-004-40002 Supplier Medchemexpress LLC Supplier No. HY1118231MG
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VH032 thiol (VHL ligand 6) is a VHL ligand that binds to pan-BET inhibitor JQ1 via a linker to form PROTAC. The VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.

  • Binds to pan-BET inhibitor JQ1 via a linker to form PROTAC.
  • Recruits VHL protein, a substrate recognition subunit of Cullin RING E3 ubiquitin ligase complexes.
  • Induces ubiquitination and subsequent proteasomal degradation of target proteins.

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