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Medchemexpress LLC Vh285-peg4-c4-cl | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
Supplier: Medchemexpress LLC HY11199710MM/1ML
VH285-PEG4-C4-Cl is a conjugate of ligands for E3 and 16-atom-length linker. The connector of the linker is a halogen group. It incorporates a VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM. It is able to induce 90% degradation of GFP-Halotag at 625 nM and binds to VHL with an IC50 of 0.54 μM.
- Functions as a conjugate of ligands for E3 and a 16-atom-length linker.
- Incorporates a VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
- Induces nearly complete knockdown of HaloTag7-ERK1 and HaloTag7-MEK1 at 500 nM.
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