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Medchemexpress LLC Vh285-peg4-c4-cl (haloprotac 3) | 1799506-07-2 | 96.49% | 799.42 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY111997100MG

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VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker. The connector of the linker is a Halogen group. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7, binding to VHL.

  • Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
  • Able to induce 90% degradation of GFP-Halotag at 625 nM.
  • Binds to VHL with an IC50 of 0.54 μM.
  • Treatment with 500 nM of the product is able to induce nearly complete knockdown of both HaloTag7-ERK1 and HaloTag7-MEK1.

Catalog No. 50-004-38990


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