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Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 10 MG
Supplier: Medchemexpress LLC HY11199710MG
VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker, with a Halogen group as the connector of the linker. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM, and can induce 90% degradation of GFP-Halotag at 625 nM. It binds to VHL with an IC50 of 0.54 μM.
- Conjugate of ligands for E3 and a 16-atom-length linker.
- Connector of linker is a Halogen group.
- Incorporates VHL ligand and an alkyl/ether-based linker.
- Highly potent and efficacious degrader of GFP-HaloTag7 (DC50 of 19 nM).
- Able to induce 90% degradation of GFP-Halotag at 625 nM.
- Binds to VHL with an IC50 of 0.54 μM.
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