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Medchemexpress LLC VH285-PEG4-C4-Cl (HaloPROTAC 3) | 1799506-07-2 | ≥98.0% | 799.42 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY111997

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VH285-PEG4-C4-Cl (HaloPROTAC 3) is a conjugate of ligands for E3 and a 16-atom-length linker. The connector of the linker is a Halogen group. It incorporates the VH285 based VHL ligand and an alkyl/ether-based linker. It is a highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.

  • Highly potent and efficacious degrader of GFP-HaloTag7 with a DC50 of 19 nM.
  • Able to induce 90% degradation of GFP-Halotag at 625 nM.
  • Binds to VHL with an IC50 of 0.54 μM.
  • Conjugate of ligands for E3 and 16-atom-length linker.
  • Connector of linker is halogen group.
  • Incorporates the VH285 based VHL ligand and an alkyl/ether-based linker.
  • Treatment with 500 nM can induce nearly complete knockdown of both HaloTag7-ERK1 and HaloTag7-MEK1.

Catalog No. 50-004-38726


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