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Medchemexpress LLC Vicriviroc maleate | 599179-03-0 | 98.5% | 649.70 | 5 MG
Supplier: Medchemexpress LLC 5MGHY17377
Vicriviroc maleate is a potent, selective, and orally bioavailable CCR5 antagonist. It inhibits HIV-1 in PBMC cells and demonstrates good oral availability in rats and monkeys, making it suitable for various research applications.
- Potent, selective, and orally bioavailable CCR5 antagonist with a Ki of 2.5 nM
- Inhibits HIV-1 in PBMC cells with IC90s ranging from 1.8 nM to 10 nM
- Exhibits good oral availability in rats and monkeys (10 mg/kg)
- Weak activity against hERG (IC50, 5.8 μM)
- Suppresses RANTES-induced signaling with a mean IC50 of 4.2 ± 1.3 nM
- Potently suppresses various viral isolates with geometric mean EC50s of 0.04-2.3 nM and IC90s of 0.45-18 nM
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