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Cayman Chemical VIldaglIptIn carboxylIc ACD
Supplier: Cayman Chemical 22088500 UG
An inhibitor of VEGFR2 (IC50 0 0027 M for the human receptor) selective for human VEGFR2 over mouse VEGFR2 and human VEGFR1 and VEGFR3 (IC50s 1 5 1 7 and 1 1 M respectively) as well as 40-fold selective over B-RAF RET and Tie2 inhibits VEGF-induced proliferation of HUVECs (IC50 0 01 nM) inhibits VEGF-induced increases in tissue weight and Tie2 levels in an angiogenesis chamber implant model in mice at 1 and 3 mg/kg per day inhibits primary tumor and metastasis growth in a B16 melanoma mouse model at 3 mg/kg per day
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