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Apexbio Technology LLC Vildagliptin (LAF-237) 274901-16-5 10mM (in 1mL DMSO)
Supplier: Apexbio Technology LLC A40375.1
Vildagliptin (LAF-237 CAS 274901-16-5) is an inhibitor of dipeptidyl peptidase-4 (DPP-4) a widely expressed antigenic enzyme with roles in signal transduction apoptosis and immunoregulation Vildagliptin inhibits DPP-4 enzymatic activity at an IC50 of approximately 2 3 nM preventing the degradation of glucagon-like peptide-1 (GLP-1) Through enhanced GLP-1 activity it promotes insulin secretion and reduces glucagon release Animal model studies including experiments in obese Zucker rats demonstrated improved glucose tolerance increased beta-cell proliferation decreased apoptosis and neuroprotective effects Vildagliptin is thus relevant for diabetes mellitus type 2 and related biomedical research
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