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Medchemexpress LLC Vinblastine sulfate | 143-67-9 | 99.6% | 909.05 | 100 MG
Supplier: Medchemexpress LLC HY13780R100MG
Vinblastine sulfate is a cytotoxic alkaloid effective against various cancer types. It inhibits microtubule formation and suppresses nAChR with an IC50 of 8.9 μM. This product is intended solely for research purposes.
- Inhibits microtubule formation and suppresses nAChR with an IC50 of 8.9 μM.
- Blocks mitosis in HeLa cells and induces apoptosis.
- Causes p53 alterations and DNA fragmentation, leading to apoptosis via Bax/Bcl-2 imbalance.
- Suppresses NFκB expression and its DNA binding activity.
- Triggers apoptosis through loss of mitochondrial membrane potential and activation of caspases.
- Demonstrates cytotoxicity across a broad range of human cell lines.
- Explored in various clinical trials for cancer treatment.
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