Medchemexpress LLC Vinblastine (sulfate) | 143-67-9 | 99.86% | 909.05 | 100 MG

Supplier:  Medchemexpress LLC HY13780100MG

Vinblastine sulfate is a cytotoxic alkaloid that targets various cancer types by inhibiting microtubule formation and suppressing nAChR (IC50 8.9 μM). It blocks mitosis (IC50 0.8 nM in HeLa cells), leading to cell apoptosis. For storage, keep sealed at 4°C, away from moisture and light. In solvent, store at -80°C for 6 months or -20°C for 1 month, similarly sealed. Room temperature shipping is suitable for durations under 2 weeks.

• Inhibits microtubule formation.
• Suppresses nAChR with an IC50 of 8.9 μM.
• Blocks mitosis, leading to cell apoptosis.
• Induces apoptosis via Bax/Bcl-2 imbalance.
• Suppresses NFκB expression and depresses NFκB-DNA binding activity.
• Triggers apoptosis by causing a loss of mitochondrial membrane potential and activating caspases.

Catalog No. 50-003-49644