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Apexbio Technology LLC Vinpocetine 42971-09-5 100mg
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Supplier:  Apexbio Technology LLC B2276100

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Vinpocetine (CAS 42971-09-5) is a selective inhibitor of cyclic GMP phosphodiesterase (PDE) exhibiting a Ki of 14 2 M for Ca2 -dependent PDE in vitro It acts as a non-competitive inhibitor effectively modulating intracellular cGMP levels in smooth muscle In rat aortic cytosolic preparations vinpocetine inhibits Ca2 -PDE activity significantly while demonstrating minimal inhibition of Ca2 -independent cGMP PDE and cAMP PDE (Ki values 1000 M) Additionally vinpocetine attenuates 5-HT-induced contractions in intact rat aorta with an EC50 of 1 M This compound is used in research to explore mechanisms of smooth muscle relaxation and PDE regulation

Catalog No. 50-224-0828


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