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AdipoGen VIP (human, mouse, rat) . AcOH [RLF-100] (5 mg)
SDP

Supplier:  AdipoGen AGCP30041M005

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Chemical. CAS: 1444827-29-5 | 40077-57-4 (free base). Formula: C147H238N44O42S . C2H4O2. MW: 3325.8 . 60.0. Vasoactive intestinal peptide (VIP) is a 28 amino acid peptide that belongs to secretin-glucagon-CRF superfamily, the ligand of class II G protein-coupled receptors subclass B1. VIP binds to the receptors VPAC1, VPAC2 and with less sensitivity to PAC1, which trigger a G-alpha-mediated signalling cascade, eventually activating adenyl cyclase leading to increases in cAMP and PKA. The PKA then activates other intracellular signaling pathways like the phosphorylation of CREB and other transcriptional factors. VIP (RLF-100; Aviptadil) provides rapid respiratory failure reduction in clinically ill patients with COVID-19 and blocks replication of the SARS-CoV-2 virus in human lung cells and monocytes. Therefore it is beeing investigated in clinical trials for the treatment of Acute Respiratory Distress Syndrome (ARDS) in COVID-19.

Catalog No. 50-205-3743


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