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Medchemexpress LLC Voacamine | 3371-85-5 | 5 MG
Supplier: Medchemexpress LLC HYN69325MG
Voacamine is an indole alkaloid with cannabinoid 1 (CB1) antagonistic activity. It can inhibit nuclear translocation. Voacamine enhances the effect of Doxorubicin by interfering with P-glycoprotein (P-gp) function. It promotes apoptosis-independent autophagic cell death in human osteosarcoma cells. Voacamine activates the mitochondrial-associated apoptosis signaling pathway and inhibits the PI3K/Akt/mTOR signaling pathway to suppress breast cancer progression. Additionally, Voacamine inhibits EGFR to exert oncogenic activity against colorectal cancer.
- Indole alkaloid
- Acts as a cannabinoid 1 (CB1) antagonist
- Enhances Doxorubicin effect through P-gp interference
- Promotes autophagic cell death in osteosarcoma cells
- Suppresses breast cancer progression by inhibiting PI3K/Akt/mTOR signaling
- Exerts oncogenic activity against colorectal cancer by inhibiting EGFR
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