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Medchemexpress LLC Vociprotafib | 2172652-48-9 | 99.7% | C20H27ClN6O2S | 50 MG
Supplier: Medchemexpress LLC HY14152350MG
Vociprotafib is an orally active, selective, and potent phosphatase SHP2 inhibitor. It blocks the activation of the RAS-RAF-MEK-ERK signaling pathway, demonstrating antitumor activity. It has been shown to accelerate tumor regressions in Osimertinib-sensitive EGFR-mutant tumors in mice and delays or reduces tumor regrowth upon cessation of treatment.
- Selective and potent SHP2 inhibitor
- Blocks RAS-RAF-MEK-ERK signaling pathway activation
- Accelerates tumor regressions in Osimertinib-sensitive EGFR-mutant tumors
- Delays and/or reduces tumor regrowth
- Effective in PDX models with resistance to Osimertinib via c-MET amplification
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