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Medchemexpress LLC Vociprotafib (RMC-4630) | 2172652-48-9 | 99.70% | C20H27ClN6O2S | 100 MG
Supplier: Medchemexpress LLC HY141523100MG
Vociprotafib (RMC-4630) is an orally active, selective, and potent phosphatase SHP2 inhibitor. It functions by blocking the activation of the RAS-RAF-MEK-ERK signaling pathway, demonstrating antitumor activity. This compound accelerates tumor regressions in Osimertinib-sensitive EGFR-mutant tumors and delays tumor regrowth after treatment.
- Orally active, selective, and potent phosphatase SHP2 inhibitor
- Blocks activation of the RAS-RAF-MEK-ERK signaling pathway
- Demonstrates antitumor activity
- Accelerates tumor regressions in EGFR-mutant tumors
- Delays tumor regrowth after treatment cessation
- Effective against tumors resistant to Osimertinib via c-MET amplification
- Investigated in a phase 1 clinical trial for KRAS-mutant non-small cell lung cancer
- Considered a foundational approach for targeted therapy combinations in RAS pathway driven cancers
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