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Cayman Chemical VorasIdenIb 10mg
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Supplier:  Cayman Chemical 2846210 MG

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An inhibitor of mutant IDH (IC50s = 31.9 and 31.7 nM for IDH1R132H and IDH2R140Q, respectively); inhibits wild-type-IDH1R132H and wild-type-IDH2R140Q heterodimers (IC50s = 4 and 251 nM, respectively); decreases the production of 2-HG in TF-1 leukemia cells expressing IDH1R132H or IDH2R140Q (IC50s = 3.2 and 14 nM, respectively); reduces tumor growth in a TS603-IDH1R132H mouse xenograft model at 50 mg/kg

Catalog No. 50-294-1165


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