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Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.58% | 437.90 | 50 MG
SDP

Catalog No. 5000392162
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Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

  • Inhibits topoisomerase II activity.
  • Induces site-selective DNA DSB.
  • Causes G2 arrest.
  • Leads to apoptosis.
  • Shows potent cytotoxic activity in AML cell lines.
  • Exhibits additive or synergistic activity with cytarabine in acute leukemia cell lines.
  • Reduces bone marrow cellularity in mice.
  • Causes reversible decrease in myeloid and lymphoid cells in vivo.

Catalog No. 50-003-92162 Supplier Medchemexpress LLC Supplier No. HY1651850MG
May include imposed supplier surcharges.
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Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

  • Inhibits topoisomerase II activity.
  • Induces site-selective DNA DSB.
  • Causes G2 arrest.
  • Leads to apoptosis.
  • Shows potent cytotoxic activity in AML cell lines.
  • Exhibits additive or synergistic activity with cytarabine in acute leukemia cell lines.
  • Reduces bone marrow cellularity in mice.
  • Causes reversible decrease in myeloid and lymphoid cells in vivo.

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