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Medchemexpress LLC Voreloxin Hydrochloride | 175519-16-1 | 99.58% | 437.90 | 50 MG
Supplier: Medchemexpress LLC HY1651850MG
Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.
- Inhibits topoisomerase II activity.
- Induces site-selective DNA DSB.
- Causes G2 arrest.
- Leads to apoptosis.
- Shows potent cytotoxic activity in AML cell lines.
- Exhibits additive or synergistic activity with cytarabine in acute leukemia cell lines.
- Reduces bone marrow cellularity in mice.
- Causes reversible decrease in myeloid and lymphoid cells in vivo.
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