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Medchemexpress LLC Voreloxin hydrochloride | 175519-16-1 | 99.6% | 437.90 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY16518

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Voreloxin Hydrochloride is a first-in-class topoisomerase II inhibitor that intercalates DNA and induces site-selective DNA double-strand breaks, G2 arrest, and apoptosis.

  • Induces G2 arrest partially through topoisomerase II in A549 lung cancer cell line.
  • Cytotoxic activity requires DNA intercalation.
  • Exhibits potent cytotoxic activity in AML cell lines, including MV4-11 and HL-60.
  • Shows additive or synergistic activity in acute leukemia cell lines when combined with cytarabine.
  • Causes accumulation of cells in the S and G2 phases of the cell cycle.
  • Induces bone marrow aplasia in vivo when combined with cytarabine.

Catalog No. 50-003-93058


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