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Voriconazole, 98%, Thermo Scientific Chemicals

Catalog No. AC458670010
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Quantity:
1 g

Voriconazole, CAS # 137234-62-9, is an antifungalagent that acts by inhibition of sterol biosynthesis.

This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. Some documentation and label information may refer to the legacy brand. The original Acros Organics product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

General Description

  • Voriconazole is an antifungal compound that has activity against a wide variety of fungal species including Aspergillus and Candida
  • Voriconazole blocks sterol biosynthesis in Candida species through inhibition of CYP450-dependent 14-alpha sterol demethylase
  • It depletes the presence of ergosterol in the fungal cell membrane, which can lead to death or growth inhibition, depending on the organism

Applications

  • Voriconazole may be used in laboratory studies of drug safety, pharmacokinetics, and mechanism of action
TRUSTED_SUSTAINABILITY

Chemical Identifiers

CAS 137234-62-9
Molecular Formula C16H14F3N5O
Molecular Weight (g/mol) 349.317
InChI Key BCEHBSKCWLPMDN-MGPLVRAMSA-N
PubChem CID 71616
ChEBI CHEBI:10023
IUPAC Name (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol
SMILES CC(C1=NC=NC=C1F)C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O

Specifications

Type Voriconazole
Melting Point 128.0°C to 134.0°C
Infrared Spectrum Authentic
Loss on Drying 0.5% max.
Quantity 1 g
Solubility Information Solubility in water: insoluble in water. Other solubilities: soluble in methanol,acetonitrile
Formula Weight 349.31
Percent Purity 98%
Chemical Name or Material Voriconazole
Hazard Category Danger
Hazard Statement GHS H Statement Toxic if swallowed. Suspected of causing cancer. May damage fertility or the unborn child. May cause damage to organs through prolonged or repeated exposure. Harmful to aquatic life with long lasting effects.
Precautionary Statement GHS P Statement Wash face, hands and any exposed skin thoroughly after handling. IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. Obtain special instructions before use. Use personal protective equipment as required. Avoid release to the environment.

RUO – Research Use Only

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