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Apexbio Technology LLC Vortioxetine (Lu AA21004) HBr 960203-27-4 25mg
Supplier: Apexbio Technology LLC A254725
Vortioxetine (Lu AA21004) HBr (CAS 960203-27-4) is a multimodal antidepressant that modulates the serotonergic system It acts as an antagonist at the human 5-HT3A (Ki 3 7 nM) and 5-HT7 receptors (Ki 19 nM) a partial agonist at the 5-HT1B receptor (Ki 33 nM EC50 460 nM) an agonist at 5-HT1A (Ki 15 nM) and inhibits the serotonin transporter (hSERT Ki 1 6 nM) In cellular assays it demonstrates functional antagonism at 5-HT7 and partial agonism at 5-HT1B In vivo vortioxetine modulates serotonergic activity in rodents with ED50 values of 0 4 mg/kg for rSERT and 0 11 mg/kg for 5-HT3 It is utilized in neuropharmacological studies to investigate serotonergic signaling and depression-related mechanisms
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