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AdipoGen VSTM5 hFc h non-lytic
Supplier: AdipoGen AG40B0237C050
Recombinant protein. The extracellular domain of human VSTM5 aa 29-147 is fused to the N-terminus of the human Fc IgG1 non-lytic mutant. Source HEK 293 cells. Lyophilized. Contains PBS. The V-set and transmembrane domain-containing protein VSTM family is composed of 8 proteins VSTM1v1, VSTM1v2, VSTM2a, VSTM2b, VSTM2L, VSTM3, VSTM4 and VSTM 5. Members of the VSTM family are associated with the regulation of functions of immune cells, adipose cells and neuronal cells. The VSTM family is an immunoglobulin Ig superfamily that shares structural similarities with the B7-like transmembrane proteins involved in immune regulation. VSTM1 and VSTM4 play positive and negative roles in macrophage activation, respectively. VSTM3 TIGIT acts as a co-inhibitory receptor that suppresses the cytokine production of T cells and NK cells.
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