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Medchemexpress LLC VTP50469 | 2169916-18-9 | 99.7% | 630.82 | 50 MG
Supplier: Medchemexpress LLC HY11416250MG
VTP50469 is a potent, highly selective, and orally active Menin-MLL interaction inhibitor with a Ki of 104 pM. It demonstrates potent anti-leukemia activity.
- Potent, highly selective, and orally active menin-MLL interaction inhibitor.
- Ki of 104 pM against menin-MLL interaction.
- Potent anti-leukemia activity.
- Inhibits cell proliferation in MLL-r cell lines and ALL cell lines in a concentration-dependent manner.
- Induces apoptosis in MLL-r B cell ALL (B-ALL) cell lines.
- Induces dose-dependent differentiation in MLL-r AML cell lines.
- Displaces menin from protein complexes and inhibits chromatin occupancy of MLL at select genes, leading to changes in gene expression, differentiation, and apoptosis.
- Highly efficacious in NSG mice with MV4;11 cells, extending survival advantage.
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