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Medchemexpress LLC VTP50469 fumarate | 2169919-29-1 | 99.8% | 804.93 | 100 MG
Supplier: Medchemexpress LLC HY114162A100MG
VTP50469 fumarate is a potent, highly selective, and orally active Menin-MLL interaction inhibitor. It demonstrates potent anti-leukemia activity with a Ki of 104 pM.
- Inhibits cell proliferation in MLL-r and ALL cell lines
- Induces apoptosis in MLL-r B cell ALL cell lines
- Causes dose-dependent differentiation in MLL-r AML cell lines
- Displaces Menin from protein complexes and inhibits chromatin occupancy of MLL
- Leads to changes in gene expression, differentiation, and apoptosis
- Shows significant survival advantage in in vivo studies in NSG mice
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