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Apexbio Technology LLC VU 0155069 1130067-06-9 10mg
Supplier: Apexbio Technology LLC B743410
VU 0155069 (CAS 1130067-06-9) is a selective inhibitor of phospholipase D1 (PLD1) with an IC50 of 46 nM PLD1 regulates the production of phosphatidic acid a lipid mediator involved in signal transduction by G protein-coupled and receptor tyrosine kinases At 200 nM VU 0155069 preferentially inhibits PLD1 activity over PLD2 evidenced by decreased PLD1-driven migration in 4T1 cells At higher concentrations (20 M) it inhibits both PLD isoforms in Calu-1 and HEK293-gfpPLD2 cells In hepatocellular carcinoma xenograft models VU 0155069 administration significantly reduced tumor size and proliferation markers This compound is valuable for investigating PLD1-mediated cellular processes and cancer progression
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