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Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.7% | 342.44 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY16689100MG

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VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) that is selective versus NKCC1. It also inhibits hERG and L-type Ca2+ channels, making it a valuable tool in neuroscience research. This compound attenuates GABA-induced hyperpolarization of P cells, produces a positive shift in the P cell GABA reversal potential, and enhances P cell synaptic transmission.

  • Potent neuronal K-Cl cotransporter KCC2 inhibitor
  • Selective inhibition over NKCC1
  • Inhibits hERG and L-type Ca2+ channels
  • Attenuates GABA-induced hyperpolarization of P cells
  • Enhances P cell synaptic transmission

Catalog No. 50-003-92430


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