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Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.7% | 342.44 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1668950MG

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VU 0240551 is a potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM) that exhibits selectivity over NKCC1. It also acts as an inhibitor of hERG and L-type Ca2+ channels. This compound reduces GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and an enhancement of P cell synaptic transmission. It is intended for research use only.

  • Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
  • Selective against NKCC1
  • Inhibits hERG and L-type Ca2+ channels
  • Attenuates GABA-induced hyperpolarization of P cells
  • Produces a positive shift in the P cell GABA reversal potential
  • Enhances P cell synaptic transmission

Catalog No. 50-003-92428


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