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Medchemexpress LLC VU 0240551 | 893990-34-6 | 99.70% | 342.44 | 10 MM * 1 ML
SDP

Catalog No. 5000392476
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VU 0240551 is a potent inhibitor of the neuronal K-Cl cotransporter KCC2, with an IC50 of 560 nM, and demonstrates selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. This compound attenuates GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and enhancing P cell synaptic transmission.

  • Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
  • Selective versus NKCC1
  • Inhibits hERG and L-type Ca2+ channels
  • Attenuates GABA-induced hyperpolarization of P cells
  • Produces a positive shift in the P cell GABA reversal potential
  • Enhances P cell synaptic transmission
  • For research use only

Catalog No. 50-003-92476 Supplier Medchemexpress LLC Supplier No. HY1668910MM/1ML
May include imposed supplier surcharges.
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VU 0240551 is a potent inhibitor of the neuronal K-Cl cotransporter KCC2, with an IC50 of 560 nM, and demonstrates selectivity against NKCC1. It also inhibits hERG and L-type Ca2+ channels. This compound attenuates GABA-induced hyperpolarization of P cells, leading to a positive shift in the P cell GABA reversal potential and enhancing P cell synaptic transmission.

  • Potent neuronal K-Cl cotransporter KCC2 inhibitor (IC50=560 nM)
  • Selective versus NKCC1
  • Inhibits hERG and L-type Ca2+ channels
  • Attenuates GABA-induced hyperpolarization of P cells
  • Produces a positive shift in the P cell GABA reversal potential
  • Enhances P cell synaptic transmission
  • For research use only

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